Gentamicin Sulfate Solution（50mg/ml）
Mol. Weight: 575.67
Appearance: Clear-Colorless Solution
Other Notes: This product is sterile
Gentamicin Sulfate is an
aminoglycoside antibiotic that is effective against many Gram-negative
bacteria, e.g., Brucella, Escherichia, Enterobacter, Francisella, Yersinia, etc., and some strains of
staphylococci. It inhibits the initiation, elongation and termination of
protein synthesis by binding to the 30S subunit and sometimes the 50S subunit
of the bacterial ribosome.
Gentamicin is suitable for plant
tissue culture use as it is stable for autoclaving; however, it has been
reported that gentamicin inhibits growth of tobacco, sapiglossis, romaine
lettuce and artichoke at high concentration ranging from 50 to 100 μg/mL.
Minimum inhibitory concentration
(MIC) of gentamicin has been reported for many bacteria. MIC for Escherichia coli is 0.05 μg/mL, Bacteroides spp. is greater than 128
μg/mL, and Clostridium spp. is 112
A. Eichholtz, Paul M. Hasegawa and Henry A. Robitaille. 1982. Effects of gentamicin on growth of shoot initiation
from cultured tobacco callus and Salpiglossis leaf discs. In
Vitro Cellular & Developmental Biology – Plant. 18(1):12-14
2. J. H. Dodds and L. W.
Roberts. 1981. Some inhibitory effects
of gentamicin on plant tissue cultures. In Vitro Cellular & Developmental
Biology – Plant. 17(6):467-470